G Protein β3 Subunit 825T Allele and Hypertension
نویسندگان
چکیده
منابع مشابه
G-protein beta3-subunit gene 825T allele and hypertension: a longitudinal study in young grade I hypertensives.
The 825T allele of the GNB3 gene has been associated with essential hypertension and obesity in cross-sectional studies. We have therefore planned a longitudinal cohort study to assess whether the GNB3 825T allele is predictive of blood pressure increase in young subjects with grade I hypertension. We genotyped at the GNB3 825 locus 461 participants of the Hypertension and Ambulatory Recording ...
متن کاملG-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension.
The C825T polymorphism of the gene encoding the G-protein beta(3) subunit (GNB3) is associated with increased intracellular signal transduction and arterial hypertension. The aim of the study was to investigate the impact of this polymorphism on early adaptive processes of the left ventricle and renal hemodynamic changes in young normotensive to mildly hypertensive subjects. Ninety-five white m...
متن کاملG Protein b3 Subunit 825T Allele and Enhanced Coronary Vasoconstriction on a2-Adrenoceptor Activation
Recently, a2-adrenoceptor activation was shown to play an important role in the vasoconstriction of normal coronary arteries, whereas in the presence of atherosclerosis, the activation of both a1and a2-adrenoceptors reduces coronary blood flow in humans. a2-Adrenoceptors activate pertussis toxin (PTX)-sensitive G proteins, whereas a1-adrenoceptors couple to PTX-insensitive G proteins. Thus, the...
متن کاملAssociation of maternal G protein beta3 subunit 825T allele with low birthweight.
Weight at birth has been associated with an increased risk for cardiovascular disease and type 2 diabetes in adult life. We found an association between the maternal G protein beta3 subunit 825T allele and low birthweight in babies born to women without other risks for reduced fetal growth.
متن کاملMetabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein β3 subunit
BACKGROUND A C825T polymorphism was recently identified in the gene encoding the beta3 subunit of heterotrimeric G-proteins (GNB3). The T-allele is significantly associated with essential hypertension and obesity. In order to further explore a possible pathogenetic link between the T-allele and impaired glucose tolerance we studied metabolic and haemodynamic responses to oral glucose loading in...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.34.5.e8